Altered TNF-α, glucose, insulin, and amino acids in islets of Langerhans cultured in a microgravity model system

The present studies were designed to determine effects of a microgravity model system upon lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) activity and indexes of insulin and fuel homeostasis of pancreatic islets of Langerhans. These alterations in fuel homeostasis may be...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2001, Vol.43 (1), p.E92-E102
Hauptverfasser:	TOBIN, Brian W, LEEPER-WOODFORD, Sandra K, HASHEMI, Brian B, SMITH, Scott M, SAMS, Clarence F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Applied physiology Biological and medical sciences Cytokines Diabetes Glucose Human physiology applied to population studies and life conditions. Human ecophysiology Insulin Medical sciences Transports. Aerospace. Diving. Altitude Tumors
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Zusammenfassung:	The present studies were designed to determine effects of a microgravity model system upon lipopolysaccharide (LPS)-stimulated tumor necrosis factor-alpha (TNF-alpha) activity and indexes of insulin and fuel homeostasis of pancreatic islets of Langerhans. These alterations in fuel homeostasis may be promulgated by gravity-averaged cell culture methods or by three-dimensional cell assembly.
ISSN:	0193-1849 1522-1555