In vivo measurement of fatty acids and cholesterol synthesis using D(2)O and mass isotopomer analysis

In vivo measurement of fatty acids and cholesterol synthesis using D(2)O and mass isotopomer analysis

The results of a study using Sprague-Dawley rats indicate that mass isotopomer distribution analysis and deuterated water can be used not only to quantitate the replacement rate of many lipids in various compartments but may also be used to elucidate the tissue-specific synthetic pathways from the m...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 1994-05, Vol.29 (5), p.E699
Hauptverfasser: Lee, W N Paul, Bassilian, Sara, Ajie, Henry O, Schoeller, Dale A
Format: Artikel
Sprache:eng
Schlagworte:
Cholesterol
Lipids
Medical research
Metabolism
Rodents
Water
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Zusammenfassung:The results of a study using Sprague-Dawley rats indicate that mass isotopomer distribution analysis and deuterated water can be used not only to quantitate the replacement rate of many lipids in various compartments but may also be used to elucidate the tissue-specific synthetic pathways from the maximum incorporation number.
ISSN:0193-1849
1522-1555