Effect of a glucokinase inhibitor on energy production and insulin release in pancreatic islets

The results of a study are consistent with a model in which the primary importance of glycolysis in transducing the glucose signal into changes of the phosphate imparts to glucokinase a high control strength on glucose-induced insulin secretion.

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 1996-09, Vol.34 (3), p.E606
Hauptverfasser: Sweet, Ian R, Li, Guizhu, Najafi, Habiba, Berner, Donna, Matschinsky, Franz M
Format: Artikel
Sprache:eng
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Zusammenfassung:The results of a study are consistent with a model in which the primary importance of glycolysis in transducing the glucose signal into changes of the phosphate imparts to glucokinase a high control strength on glucose-induced insulin secretion.
ISSN:0193-1849
1522-1555