Parenteral nutrition with lipid or glucose suppresses liver growth and response to GH in adolescent male rats

Our aim was to investigate the effects of modifying the carbohydrate-to-lipid ratio of parenteral nutrition (PN) on body composition and the anabolic actions of insulin-like growth factor I (IGF-I) and growth hormone (GH). Adolescent male Sprague-Dawley rats were randomized to receive 7 days of GH,...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2001-11, Vol.44 (5), p.E1063-E1072
Hauptverfasser:	SEVETTE, Andre, KEE, Anthony J, CARLSSON, Anthony R, BAXTER, Robert C, SMITH, Ross C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Glucose Intensive care medicine Lipids Liver Medical sciences Physical growth Rodents
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description	Our aim was to investigate the effects of modifying the carbohydrate-to-lipid ratio of parenteral nutrition (PN) on body composition and the anabolic actions of insulin-like growth factor I (IGF-I) and growth hormone (GH). Adolescent male Sprague-Dawley rats were randomized to receive 7 days of GH, IGF-I (3.5 mg-kg(-1)-day(-1) for both) or placebo while receiving high-carbohydrate PN (CHO-PN), high-lipid PN (L-PN), or an oral diet (chow) (the PN protocols were isonitrogenous and isocaloric).
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Enteral and parenteral nutrition</subject><subject>Glucose</subject><subject>Intensive care medicine</subject><subject>Lipids</subject><subject>Liver</subject><subject>Medical sciences</subject><subject>Physical growth</subject><subject>Rodents</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNotkE1LxDAQhoMouK7-hyB4LDRfTXOURXeFBT3svUzbqWbJJjFpXfz3BlzmMDDPwzvDXJEVU5xXTCl1TVY1M6JirTS35C7nY13XWkm-IqcPSOhnTOCoX-ZkZxs8Pdv5izob7UhDop9uGUJGmpcYE-aMubAfLCCFcxHBj7TMY_BFmgPd7qj1FMbgMA8lnJ7AIU0w53tyM4HL-HDpa3J4fTlsdtX-ffu2ed5XUWlZGa5byTgzBsuZGnQ9tlLqvoEWDZhe8wHGXhmUemo4mgJEb3QrGt3Uig1iTR7_Y2MK3wvmuTuGJfmyseOilFJCFunpIkEewE0J_GBzF5M9QfrtmGSqPFCIPxTkYqI</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>SEVETTE, Andre</creator><creator>KEE, Anthony J</creator><creator>CARLSSON, Anthony R</creator><creator>BAXTER, Robert C</creator><creator>SMITH, Ross C</creator><general>American Physiological Society</general><scope>IQODW</scope><scope>7QP</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20011101</creationdate><title>Parenteral nutrition with lipid or glucose suppresses liver growth and response to GH in adolescent male rats</title><author>SEVETTE, Andre ; KEE, Anthony J ; CARLSSON, Anthony R ; BAXTER, Robert C ; SMITH, Ross C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p574-9278412199e0077a70d8447b6a8e9a9b72cadb59e47f62e9b6a3b9783676051c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia. 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subjects	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Glucose Intensive care medicine Lipids Liver Medical sciences Physical growth Rodents
title	Parenteral nutrition with lipid or glucose suppresses liver growth and response to GH in adolescent male rats
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