Parenteral nutrition with lipid or glucose suppresses liver growth and response to GH in adolescent male rats

Our aim was to investigate the effects of modifying the carbohydrate-to-lipid ratio of parenteral nutrition (PN) on body composition and the anabolic actions of insulin-like growth factor I (IGF-I) and growth hormone (GH). Adolescent male Sprague-Dawley rats were randomized to receive 7 days of GH,...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2001-11, Vol.44 (5), p.E1063-E1072
Hauptverfasser:	SEVETTE, Andre, KEE, Anthony J, CARLSSON, Anthony R, BAXTER, Robert C, SMITH, Ross C
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition Glucose Intensive care medicine Lipids Liver Medical sciences Physical growth Rodents
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Beschreibung
Zusammenfassung:	Our aim was to investigate the effects of modifying the carbohydrate-to-lipid ratio of parenteral nutrition (PN) on body composition and the anabolic actions of insulin-like growth factor I (IGF-I) and growth hormone (GH). Adolescent male Sprague-Dawley rats were randomized to receive 7 days of GH, IGF-I (3.5 mg-kg(-1)-day(-1) for both) or placebo while receiving high-carbohydrate PN (CHO-PN), high-lipid PN (L-PN), or an oral diet (chow) (the PN protocols were isonitrogenous and isocaloric).
ISSN:	0193-1849 1522-1555