Induction of Ca-independent PLA2 and conservation of plasmalogen polyunsaturated fatty acids in diabetic heart

Diabetes-induced changes in phospholipase A2 (PLA2) activity have been measured in several tissues but are undefined in diabetic myocardium. We measured ventricular PLA2 activity in control, streptozotocin-induced diabetic and insulin-treated diabetic rats and characterized myocardial phospholipids...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2000-07, Vol.42 (1), p.E25-E32
Hauptverfasser:	MCHOWAT, J, CREER, M. H, HICKS, K. K, JONES, J. H, MCCRORY, R, KENNEDY, R. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Associated diseases and complications Biological and medical sciences Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Fatty acids Heart Medical sciences
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Zusammenfassung:	Diabetes-induced changes in phospholipase A2 (PLA2) activity have been measured in several tissues but are undefined in diabetic myocardium. We measured ventricular PLA2 activity in control, streptozotocin-induced diabetic and insulin-treated diabetic rats and characterized myocardial phospholipids to determine whether diabetes altered myocardial phospholipid metabolism.
ISSN:	0193-1849 1522-1555