Correlation between GABA release from rat islet β-cells and their metabolic state

Correlation between GABA release from rat islet β-cells and their metabolic state

Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). Over a 24-h culture period, total GABA release by purified rat beta-cells is eightfold higher than the cellular GABA content and can thus be used as an...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2002-04, Vol.45 (4), p.E937-E942
Hauptverfasser: WINNOCK, Frederic, ZHIDONG LING, DE PROFT, Rene, DEJONGHE, Sandra, SCHUIT, Frans, GORUS, Frans, PIPELEERS, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Clinical trials
Diabetes
Insulin
Metabolism
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Zusammenfassung:Pancreatic beta-cells express glutamate decarboxylase (GAD), which is responsible for the production and release of gamma-aminobutyric acid (GABA). Over a 24-h culture period, total GABA release by purified rat beta-cells is eightfold higher than the cellular GABA content and can thus be used as an index of cellular GAD activity.
ISSN:0193-1849
1522-1555