Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release
The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Fur...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 1998-04, Vol.37 (4), p.E751 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 4 |
| container_start_page | E751 |
| container_title | American journal of physiology: endocrinology and metabolism |
| container_volume | 37 |
| creator | Efanov, Alexandre M Zaitsev, Sergei V Efanova, Ioulia B Zhu, Shunsheng |
| description | The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Furthermore, we studied the interaction of the compounds on these two parameters. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_232316692</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>30941102</sourcerecordid><originalsourceid>FETCH-proquest_journals_2323166923</originalsourceid><addsrcrecordid>eNqNzr0KwjAUBeAgCtafdwjuhSRt-jOL4qwObiXobU2JieYmg29vqT6A0x3Odw53QhIuhUi5lHJKEsbrLOVVXs_JArFnjJUyFwnpTrqzymjbUWVvFHUApK6l2gbw6hq0s7R1nh4vaVVyJvIvi6Z19m2iBzVQGu5AMehHNGpsjAMDGiIPBhTCisxaZRDWv7skm_3uvD2kT-9eETA0vYt--AQbkYmMF0Utsr_QBwlZR3I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232316692</pqid></control><display><type>article</type><title>Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release</title><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Efanov, Alexandre M ; Zaitsev, Sergei V ; Efanova, Ioulia B ; Zhu, Shunsheng</creator><creatorcontrib>Efanov, Alexandre M ; Zaitsev, Sergei V ; Efanova, Ioulia B ; Zhu, Shunsheng</creatorcontrib><description>The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Furthermore, we studied the interaction of the compounds on these two parameters.</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>CODEN: AJPMD9</identifier><language>eng</language><publisher>Bethesda: American Physiological Society</publisher><subject>Diabetes ; Endocrine system ; Insulin ; Medical research</subject><ispartof>American journal of physiology: endocrinology and metabolism, 1998-04, Vol.37 (4), p.E751</ispartof><rights>Copyright American Physiological Society Apr 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Efanov, Alexandre M</creatorcontrib><creatorcontrib>Zaitsev, Sergei V</creatorcontrib><creatorcontrib>Efanova, Ioulia B</creatorcontrib><creatorcontrib>Zhu, Shunsheng</creatorcontrib><title>Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release</title><title>American journal of physiology: endocrinology and metabolism</title><description>The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Furthermore, we studied the interaction of the compounds on these two parameters.</description><subject>Diabetes</subject><subject>Endocrine system</subject><subject>Insulin</subject><subject>Medical research</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNqNzr0KwjAUBeAgCtafdwjuhSRt-jOL4qwObiXobU2JieYmg29vqT6A0x3Odw53QhIuhUi5lHJKEsbrLOVVXs_JArFnjJUyFwnpTrqzymjbUWVvFHUApK6l2gbw6hq0s7R1nh4vaVVyJvIvi6Z19m2iBzVQGu5AMehHNGpsjAMDGiIPBhTCisxaZRDWv7skm_3uvD2kT-9eETA0vYt--AQbkYmMF0Utsr_QBwlZR3I</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Efanov, Alexandre M</creator><creator>Zaitsev, Sergei V</creator><creator>Efanova, Ioulia B</creator><creator>Zhu, Shunsheng</creator><general>American Physiological Society</general><scope>7QP</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19980401</creationdate><title>Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release</title><author>Efanov, Alexandre M ; Zaitsev, Sergei V ; Efanova, Ioulia B ; Zhu, Shunsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_2323166923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Diabetes</topic><topic>Endocrine system</topic><topic>Insulin</topic><topic>Medical research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Efanov, Alexandre M</creatorcontrib><creatorcontrib>Zaitsev, Sergei V</creatorcontrib><creatorcontrib>Efanova, Ioulia B</creatorcontrib><creatorcontrib>Zhu, Shunsheng</creatorcontrib><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Efanov, Alexandre M</au><au>Zaitsev, Sergei V</au><au>Efanova, Ioulia B</au><au>Zhu, Shunsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><date>1998-04-01</date><risdate>1998</risdate><volume>37</volume><issue>4</issue><spage>E751</spage><pages>E751-</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><coden>AJPMD9</coden><abstract>The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Furthermore, we studied the interaction of the compounds on these two parameters.</abstract><cop>Bethesda</cop><pub>American Physiological Society</pub></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 1998-04, Vol.37 (4), p.E751 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_proquest_journals_232316692 |
| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Diabetes Endocrine system Insulin Medical research |
| title | Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T07%3A11%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Signaling%20and%20sites%20of%20interaction%20for%20RX-871024%20and%20sulfonylurea%20in%20the%20stimulation%20of%20insulin%20release&rft.jtitle=American%20journal%20of%20physiology:%20endocrinology%20and%20metabolism&rft.au=Efanov,%20Alexandre%20M&rft.date=1998-04-01&rft.volume=37&rft.issue=4&rft.spage=E751&rft.pages=E751-&rft.issn=0193-1849&rft.eissn=1522-1555&rft.coden=AJPMD9&rft_id=info:doi/&rft_dat=%3Cproquest%3E30941102%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=232316692&rft_id=info:pmid/&rfr_iscdi=true |