Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release

Signaling and sites of interaction for RX-871024 and sulfonylurea in the stimulation of insulin release

The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Fur...

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Veröffentlicht in:American journal of physiology: endocrinology and metabolism 1998-04, Vol.37 (4), p.E751
Hauptverfasser: Efanov, Alexandre M, Zaitsev, Sergei V, Efanova, Ioulia B, Zhu, Shunsheng
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
Endocrine system
Insulin
Medical research
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Zusammenfassung:The objective of this study was to compare effects of RX-871024, a compound with imidazoline structure, and the sulfonylurea glibenclamide, representatives of two groups of ATP-dependent potassium channel (KATp) blockers, on insulin secretion and cytoplasmic free calcium concentration (ACa2+Bi). Furthermore, we studied the interaction of the compounds on these two parameters.
ISSN:0193-1849
1522-1555