N-3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle

N-3 Polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle

A high-fat diet containing polyunsaturated fatty acids )PUFA: n-3 or n-6) given for 4 wk to 5-wk-old male Wistar rats induced a clear hyperglycemia (10.4 +/- 0.001 mmol/l for n-6 rats and 10.1 +/- 0.001 for n-3 rats) and hyperinsulinemia (6.6 +/- 0.8 ng/ml for n-6 rats and 6.4 +/- 1.3 for n-3 rats),...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2002-03, Vol.45 (3), p.E664-E671
Hauptverfasser: TAOUIS, Mohammed, DAGOU, Carine, STER, Céline, DURAND, Georges, PINAULT, Michèle, DELARUE, Jacques
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Diet
Drug resistance
Fatty acids
Insulin
Liver
Muscular system
Oils & fats
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A high-fat diet containing polyunsaturated fatty acids )PUFA: n-3 or n-6) given for 4 wk to 5-wk-old male Wistar rats induced a clear hyperglycemia (10.4 +/- 0.001 mmol/l for n-6 rats and 10.1 +/- 0.001 for n-3 rats) and hyperinsulinemia (6.6 +/- 0.8 ng/ml for n-6 rats and 6.4 +/- 1.3 for n-3 rats), signs of insulin resistance. A high-fat diet (n-3) partially altered the expression of p85 but not that of GLUT-4 and leptin mRNAs in adipose tissue.
ISSN:0193-1849
1522-1555