Normal Akt/PKB with reduced PI3K activation in isulin-resistant mice

Normal Akt/PKB with reduced PI3K activation in isulin-resistant mice

Insulin stimulates muscle and adipose tissue to absorb glucose through a signaling cascade that is incompletely understood. Insulin resistance, the inability of insulin to appropriately stimulate glucose uptake, is a hallmark of type 2 diabetes mellitus.

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Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2001-12, Vol.44 (6), p.E1249
Hauptverfasser: Nadler, Samuel T, Stoehr, Jonathan P, Rabaglia, Mary E, Schueler, Kathryn L
Format: Artikel
Sprache:eng
Schlagworte:
Diabetes
Enzymes
Glucose
Insulin
Proteins
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Beschreibung
Zusammenfassung:Insulin stimulates muscle and adipose tissue to absorb glucose through a signaling cascade that is incompletely understood. Insulin resistance, the inability of insulin to appropriately stimulate glucose uptake, is a hallmark of type 2 diabetes mellitus.
ISSN:0193-1849
1522-1555