Chronic inflammatory arthritis after treatment with high-dose interleukin-2 for malignancy

Interleukin-2 (IL-2) immunotherapy resulted in the development of inflammatory arthritis in three male patients with metastatic cancer. Two patients developed a clinical picture consistent with rheumatoid arthritis. A third patient with a remote history of Reiter's syndrome developed a recrudes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of medicine 1992-06, Vol.92 (6), p.693-697
Hauptverfasser:	Massarotti, Elena M., Liu, Nancy Y., Mier, James, Atkins, Michael B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Antinuclear - blood Arthritis Arthritis - blood Arthritis - chemically induced Arthritis - immunology Arthritis, Reactive - complications Biological and medical sciences Biopsy Cancer Drug therapy Drug toxicity and drugs side effects treatment Histocompatibility Testing Humans Interleukin-2 - administration & dosage Interleukin-2 - adverse effects Male Medical research Medical sciences Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Neoplasms - physiopathology Neoplasms - therapy Pharmacology. Drug treatments Phenotype Remission Induction Rheumatoid Factor - blood Synovial Fluid - chemistry Synovial Membrane - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Interleukin-2 (IL-2) immunotherapy resulted in the development of inflammatory arthritis in three male patients with metastatic cancer. Two patients developed a clinical picture consistent with rheumatoid arthritis. A third patient with a remote history of Reiter's syndrome developed a recrudescence of an inflammatory arthritis after treatment with IL-2. The clinical, laboratory, and histologic data on the patients and the potential pathophysiologic mechanisms are discussed.
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(92)90789-E