Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu

Two new alkaloids isolated from traditional Chinese medicine Binglang the fruit of Areca catechu

Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3–43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS and 1D, 2D NMR...

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Veröffentlicht in:Fitoterapia 2019-10, Vol.138, p.104276, Article 104276
Hauptverfasser: Cao, Mengru, Yuan, Hanwen, Daniyal, Muhammad, Yu, Huanghe, Xie, Qingling, Liu, Yingkai, Li, Bin, Jian, Yuqing, Peng, Caiyun, Tan, Dianbo, Peng, Yanmei, Choudhary, M. Iqbal, Rahman, Atta-ur, Wang, Wei
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Areca catechu
Arecaceae
Binglang
Catechu
Cytotoxicity
Fruits
Gastric cancer
Herbal medicine
NMR
Nuclear magnetic resonance
Structural identification
TCM
Toxicity
Traditional Chinese medicine
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Zusammenfassung:Binglang, the fruit of Areca catechu L, has a long history as an important Chinese herbal medicine. Two new alkaloids (1 and 2), along with forty-one known compounds (3–43) were isolated from the dried fruit of Areca catechu L. The structures were elucidated on basis of the IR, UV, MS and 1D, 2D NMR spectroscopic data. Compounds 26 and 33 showed weak cytotoxicity against human gastric cancer cell line (BGC-823) with IC50 of 15.91 μM and 20.13 μM, respectively. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2019.104276