Synthesis of C-ring hydrogenated sinomenine cinnamate derivatives via Heck reactions

Synthesis of C-ring hydrogenated sinomenine cinnamate derivatives via Heck reactions

The synthesis of C-ring hydrogenated sinomenine derivatives is accomplished from sinomenine by treatment with Zn-Hg/HCl, halogenation with NIS, and Heck reactions with various acrylates. A total of nine novel sinomenine cinnamate derivatives are obtained in 84%–93% yields. The structures of all the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of chemical research 2019-11, Vol.43 (11-12), p.469-473
Hauptverfasser: Pan, Hongmei, Lu, Tong, Wu, Xuedan, Jiang, Chuan, Gu, Chengwen, Zhang, Kehua, Jin, Jie
Format: Artikel
Sprache:eng
Schlagworte:
Acrylates
Chemical synthesis
Chromatography
Derivatives
Halogenation
Hydrochloric acid
Hydrogenation
NMR
Nuclear magnetic resonance
Solvents
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The synthesis of C-ring hydrogenated sinomenine derivatives is accomplished from sinomenine by treatment with Zn-Hg/HCl, halogenation with NIS, and Heck reactions with various acrylates. A total of nine novel sinomenine cinnamate derivatives are obtained in 84%–93% yields. The structures of all the derivatives are characterized by 1H NMR, 13C NMR, and MS spectroscopy.
ISSN:1747-5198
2047-6507
DOI:10.1177/1747519819868201