Metal‐Free Three‐Component Selenophenoindole Formation through Double C−H Selenylation with Selenium Powder

Metal‐Free Three‐Component Selenophenoindole Formation through Double C−H Selenylation with Selenium Powder

A facile metal‐free entry to novel selenopheno[2,3‐b]indole motif is described. The three‐component assembly of indoles, aromatic ketones, and selenium powder is enabled by the IBr‐promoted highly selective double C–H selenylation/annulation. This protocol provides a novel access to a diverse variet...

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Veröffentlicht in:Advanced synthesis & catalysis 2019-12, Vol.361 (23), p.5351-5356
Hauptverfasser: Ni, Penghui, Tan, Jing, Zhao, Wenqi, Huang, Huawen, Guo‐Jun Deng
Format: Artikel
Sprache:eng
Schlagworte:
Chemical reactions
Functional groups
Indoles
Ketones
Selenium
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Zusammenfassung:A facile metal‐free entry to novel selenopheno[2,3‐b]indole motif is described. The three‐component assembly of indoles, aromatic ketones, and selenium powder is enabled by the IBr‐promoted highly selective double C–H selenylation/annulation. This protocol provides a novel access to a diverse variety of selenopheno[2,3‐b]indoles with good efficacy and broad functional group compatibility.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201901023