Mainstreaming genetic counseling for BRCA testing into oncology clinics - Indian perspective

Mainstreaming genetic counseling for BRCA testing into oncology clinics - Indian perspective

BReastCAncer (BRCA) susceptibility genes BRCA1 and BRCA2 are mainly associated with hereditary breast and ovarian cancer (HBOC) syndrome and present an estimated 45%-65% cumulative lifetime risk of developing breast cancer and an 11%-39% risk of ovarian cancer. HBOC is also linked to triple-negative...

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Veröffentlicht in:Indian journal of cancer 2019-11, Vol.56 (5), p.38-47
Hauptverfasser: Verma, Amit, Nag, Shona, Hasan, Qurratulain, Selvakumar, Veda
Format: Artikel
Sprache:eng
Schlagworte:
BRCA2 Protein - genetics
Breast cancer
Family medical history
Female
Genetic Counseling - methods
Health risk assessment
Humans
India
Male
Middle Aged
Mutation
Ovarian cancer
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Zusammenfassung:BReastCAncer (BRCA) susceptibility genes BRCA1 and BRCA2 are mainly associated with hereditary breast and ovarian cancer (HBOC) syndrome and present an estimated 45%-65% cumulative lifetime risk of developing breast cancer and an 11%-39% risk of ovarian cancer. HBOC is also linked to triple-negative breast cancer (TNBC). BRCA1 mutations in TNBC are observed in 36% of women age
ISSN:0019-509X
1998-4774
DOI:10.4103/ijc.IJC_458_19