Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats
Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus...
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| Veröffentlicht in: | Journal of applied science & environmental management 2019-04, Vol.23 (4), p.603-609 |
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| creator | Osibemhe, M Ibrahim, M Onoagbe, IO |
| description | Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum a-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P |
| doi_str_mv | 10.4314/iasem.v23i4.4 |
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The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum a-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P<0.05) progressive decrease in fasting blood glucose concentration on the 2nd-12th weeks and 4th-12th weeks in normal and diabetic-treated rats respectively. Total cholesterol, LDL and TG levels were lowered significantly (P<0.05) by the extracts in normal and diabetic treated rats, whereas HDL levels (17.6±0.50 mg/dl) (aqueous) and (21.4±1.28 mg/dl) (ethanol) were elevated in diabetic treated rats. The activity of serum a-amylase was also elevated by the extract in diabetic treated rats. These findings indicated that SH showed hypoglycemic, anti-hyperlipidemic and anti-diabetic activities. These findings may be connected with the presence and amount of phytochemicals in the plant.</description><identifier>ISSN: 1119-8362</identifier><identifier>DOI: 10.4314/iasem.v23i4.4</identifier><language>eng</language><publisher>Port Harcourt: Dr. Michael Horsfall Jnr, University of Port Harcourt, Department of Pure and Industrial Chemistry</publisher><subject>Amylases ; Bark ; Blood ; Blood levels ; Cholesterol ; Diabetes ; Diabetes mellitus ; Ethanol ; Glucose ; High density lipoprotein ; Insulin ; Laboratory animals ; Levels ; Lipids ; Low density lipoprotein ; Males ; Metabolism ; Phytochemicals ; Rodents ; Serum ; Streptozocin ; Strophanthus hispidus ; α-Amylase</subject><ispartof>Journal of applied science & environmental management, 2019-04, Vol.23 (4), p.603-609</ispartof><rights>Copyright Dr. Michael Horsfall Jnr, University of Port Harcourt, Department of Pure and Industrial Chemistry Apr 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Osibemhe, M</creatorcontrib><creatorcontrib>Ibrahim, M</creatorcontrib><creatorcontrib>Onoagbe, IO</creatorcontrib><title>Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats</title><title>Journal of applied science & environmental management</title><description>Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum a-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P<0.05) progressive decrease in fasting blood glucose concentration on the 2nd-12th weeks and 4th-12th weeks in normal and diabetic-treated rats respectively. Total cholesterol, LDL and TG levels were lowered significantly (P<0.05) by the extracts in normal and diabetic treated rats, whereas HDL levels (17.6±0.50 mg/dl) (aqueous) and (21.4±1.28 mg/dl) (ethanol) were elevated in diabetic treated rats. The activity of serum a-amylase was also elevated by the extract in diabetic treated rats. These findings indicated that SH showed hypoglycemic, anti-hyperlipidemic and anti-diabetic activities. These findings may be connected with the presence and amount of phytochemicals in the plant.</description><subject>Amylases</subject><subject>Bark</subject><subject>Blood</subject><subject>Blood levels</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Ethanol</subject><subject>Glucose</subject><subject>High density lipoprotein</subject><subject>Insulin</subject><subject>Laboratory animals</subject><subject>Levels</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Males</subject><subject>Metabolism</subject><subject>Phytochemicals</subject><subject>Rodents</subject><subject>Serum</subject><subject>Streptozocin</subject><subject>Strophanthus hispidus</subject><subject>α-Amylase</subject><issn>1119-8362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNjr1OxDAQhF2AxPFT0q9EA0VCYluQKwME0SCdOCTK03LnU_Zw7ODdAE_BM2MhHoBqNPPNSKPUaV2V1tT2kpDdUH5oQ7a0e2pW1_W8aMyVPlCHzLuq0te2sTP13Qah4o7w1QmtYRHF5QA9tMyOecgO4hba98nFiQHDBjrpMUQP3ZckXAv_8pTiZ14TxwDnS0lxzCXp86QnHmkz8QUsfI5gKW6AG0xvQAFeiAUTPKJ38ITCx2p_i57dyZ8eqbP77vn2oRhTzBdYVrs4pZDRShtdzbW1TWP-1_oBLEdaPA</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Osibemhe, M</creator><creator>Ibrahim, M</creator><creator>Onoagbe, IO</creator><general>Dr. Michael Horsfall Jnr, University of Port Harcourt, Department of Pure and Industrial Chemistry</general><scope>7QH</scope><scope>7ST</scope><scope>7UA</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>F1W</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>L.G</scope><scope>L6V</scope><scope>M7S</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>SOI</scope></search><sort><creationdate>20190401</creationdate><title>Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats</title><author>Osibemhe, M ; Ibrahim, M ; Onoagbe, IO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_23209244883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Amylases</topic><topic>Bark</topic><topic>Blood</topic><topic>Blood levels</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Ethanol</topic><topic>Glucose</topic><topic>High density lipoprotein</topic><topic>Insulin</topic><topic>Laboratory animals</topic><topic>Levels</topic><topic>Lipids</topic><topic>Low density lipoprotein</topic><topic>Males</topic><topic>Metabolism</topic><topic>Phytochemicals</topic><topic>Rodents</topic><topic>Serum</topic><topic>Streptozocin</topic><topic>Strophanthus hispidus</topic><topic>α-Amylase</topic><toplevel>online_resources</toplevel><creatorcontrib>Osibemhe, M</creatorcontrib><creatorcontrib>Ibrahim, M</creatorcontrib><creatorcontrib>Onoagbe, IO</creatorcontrib><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Environment Abstracts</collection><jtitle>Journal of applied science & environmental management</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Osibemhe, M</au><au>Ibrahim, M</au><au>Onoagbe, IO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats</atitle><jtitle>Journal of applied science & environmental management</jtitle><date>2019-04-01</date><risdate>2019</risdate><volume>23</volume><issue>4</issue><spage>603</spage><epage>609</epage><pages>603-609</pages><issn>1119-8362</issn><abstract>Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum a-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P<0.05) progressive decrease in fasting blood glucose concentration on the 2nd-12th weeks and 4th-12th weeks in normal and diabetic-treated rats respectively. Total cholesterol, LDL and TG levels were lowered significantly (P<0.05) by the extracts in normal and diabetic treated rats, whereas HDL levels (17.6±0.50 mg/dl) (aqueous) and (21.4±1.28 mg/dl) (ethanol) were elevated in diabetic treated rats. The activity of serum a-amylase was also elevated by the extract in diabetic treated rats. These findings indicated that SH showed hypoglycemic, anti-hyperlipidemic and anti-diabetic activities. These findings may be connected with the presence and amount of phytochemicals in the plant.</abstract><cop>Port Harcourt</cop><pub>Dr. Michael Horsfall Jnr, University of Port Harcourt, Department of Pure and Industrial Chemistry</pub><doi>10.4314/iasem.v23i4.4</doi></addata></record> |
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| source | African Journals Online (Open Access); Bioline International; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Amylases Bark Blood Blood levels Cholesterol Diabetes Diabetes mellitus Ethanol Glucose High density lipoprotein Insulin Laboratory animals Levels Lipids Low density lipoprotein Males Metabolism Phytochemicals Rodents Serum Streptozocin Strophanthus hispidus α-Amylase |
| title | Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats |
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