Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats

Anti-Diabetic Potential Assessment of Aqueous and Ethanol Extracts of Arrow Poison (Strophanthus hispidus) Plant Stem Bark in Wistar Male Rats

Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus...

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Veröffentlicht in:Journal of applied science & environmental management 2019-04, Vol.23 (4), p.603-609
Hauptverfasser: Osibemhe, M, Ibrahim, M, Onoagbe, IO
Format: Artikel
Sprache:eng
Schlagworte:
Amylases
Bark
Blood
Blood levels
Cholesterol
Diabetes
Diabetes mellitus
Ethanol
Glucose
High density lipoprotein
Insulin
Laboratory animals
Levels
Lipids
Low density lipoprotein
Males
Metabolism
Phytochemicals
Rodents
Serum
Streptozocin
Strophanthus hispidus
α-Amylase
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Zusammenfassung:Diabetes mellitus is a chronic disease, for which there is no known cure except in some specific situation. The available orthodox drugs used for its management are having disadvantages. The aim of this study is to evaluate the anti-diabetic potential of aqueous and ethanol extracts of Strophanthus hispidus (SH) stem bark in Wistar male rats. Diabetes mellitus was induced by intraperitoneal injection of streptozotocin (55 mg/kg). Blood glucose concentrations, serum a-amylase and lipid profile of normal and diabetic rats were monitored for 12 weeks. The rats were treated with 250 mg/kg of aqueous and ethanol extracts of Strophanthus hispidus respectively. Dose-response study was also carried out. The results revealed significant (P
ISSN:1119-8362
DOI:10.4314/iasem.v23i4.4