Effect of alcoholic beverages on postprandial glycemia and insulinemia in lean, young, healthy adults1,2,3

Ethanol's ability to inhibit gluconeogenesis might reduce postprandial glycemia in realistic meal settings. The objective was to explore the effect of 3 types of alcoholic beverages consumed alone, with a meal, or 1 h before a meal on postprandial glycemia in healthy subjects. In study 1, isoenergetic (1000 kJ) servings of beer, white wine, and gin were compared with a 1000-kJ portion of white bread. In study 2, the same servings were compared with water as an accompaniment to a bread meal. In study 3, 20-g alcohol portions were served as a premeal drink. Fingertip capillary blood samples were taken at regular intervals over 2-3 h. In study 1, the mean (±SE) glucose scores for beer (58 ± 11), wine (7 ± 3), and gin (10 ± 5) were significantly lower (P < 0.001) than those for bread (= 100). In study 2, meals consumed with beer (84 ± 11; P = 0.03), wine (63 ± 6; P < 0.001), and gin (80 ± 12; P = 0.007) produced less glycemia than did the meal consumed with water (= 100). In study 3, all 3 beverages reduced the postprandial glycemic response to the subsequent meal (67 ± 5, 75 ± 6, and 78 ± 4 with the beer, wine, and gin trials, respectively; P < 0.003). In realistic settings, alcoholic beverage consumption lowers postprandial glycemia by 16-37%, which represents an unrecognized mechanism by which alcohol may reduce the risk of chronic disease.