A New Sesquiterpenoid from Chrysanthemum indicum
A novel glucoside sesquiterpenoid ( 1 ) was isolated from Chrysanthemum indicum L. flowers, together with 14 known compounds ( 2–15 ), among which eight compounds ( 3 , 4 , 8 , and 10–14 ) were isolated from the plant for the first time. Their structures were determined on the basis of the interpret...
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| Veröffentlicht in: | Chemistry of natural compounds 2019-11, Vol.55 (6), p.1076-1079 |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A novel glucoside sesquiterpenoid (
1
) was isolated from Chrysanthemum indicum L. flowers, together with 14 known compounds (
2–15
), among which eight compounds (
3
,
4
,
8
, and
10–14
) were isolated from the plant for the first time. Their structures were determined on the basis of the interpretation of spectroscopic data, viz., ESI-MS, HR-TOF-MS, IR, and NMR. The effects of these compounds onlipopolysaccharide-induced nitric oxide production by RAW 264.7 cells were investigated. Compounds
2
,
3
, and
7
showed strong or moderate inhibitory effects at 100 μM, and the IC
50
values of
3
and
7
were 36.09 and 9.59 μM, respectively. |
|---|---|
| ISSN: | 0009-3130 1573-8388 |
| DOI: | 10.1007/s10600-019-02898-y |