Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

A series of isoxazole-thiadiazole linked carbazole derivatives 12a – 12j are synthesized and their chemical structures confirmed by 1 H and 13 C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate)...

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Veröffentlicht in:Russian journal of general chemistry 2019-10, Vol.89 (10), p.2115-2120
Hauptverfasser: Durga Rao, B. V., Sreenivasulu, R., Basaveswara Rao, M. V.
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Cancer
Carbazoles
Care and treatment
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Etoposide
Mass spectra
NMR
Nuclear magnetic resonance
Organic chemistry
Prostate
Thiadiazoles
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Zusammenfassung:A series of isoxazole-thiadiazole linked carbazole derivatives 12a – 12j are synthesized and their chemical structures confirmed by 1 H and 13 C NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.
ISSN:1070-3632
1608-3350
DOI:10.1134/S1070363219100207