Successful treatment of post‐transplant CMV meningoencephalitis with third‐party CMV virus‐specific T cells: Lessons learned

Cytomegalovirus encephalitis is a challenging life‐threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T‐cell therapy has been reported to provide a significant chance of cure for p...

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Veröffentlicht in:	Pediatric transplantation 2019-12, Vol.23 (8), p.e13584-n/a
Hauptverfasser:	Alonso, Laura, Rudilla, Francesc, Gimeno, Ramón, Codinach, Margarita, Blanco, Margarita, Querol, Sergio, Diaz de Heredia, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	CMV Cytomegalovirus Encephalitis hematopoietic stem cell transplant Hematopoietic stem cells Lymphocytes T Meningitis Meningoencephalitis Patients Stem cell transplantation Transplants & implants virus‐specific T cells
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Beschreibung
Zusammenfassung:	Cytomegalovirus encephalitis is a challenging life‐threatening complication following hematopoietic stem cell transplantation for which medical treatment is usually ineffective or toxic. However, in recent years, adoptive T‐cell therapy has been reported to provide a significant chance of cure for patients with viral infections. Herein, two cases of pediatric patients successfully treated with third‐party donor‐derived virus‐specific T cells for CMV meningoencephalitis are reported.
ISSN:	1397-3142 1399-3046
DOI:	10.1111/petr.13584