Retracted : MicroRNA‐204‐3p represses colon cancer cells proliferation, migration, and invasion by targeting HMGA2

Colon cancer is a detrimental neoplasm of the digestive tract. MicroRNAs (miRNAs) as central regulators have been discovered in colon cancer. Nonetheless, the impact of miR‐204‐3p on colon cancer remains indistinct. The research attempted to uncover the impacts of miR‐204‐3p on colon cancer cells growth, migration, and invasion. miR‐204‐3p expression level in colon cancer tissues and diverse colon cancer cell lines were testified by the quantitative real‐time polymerase chain reaction. Exploration of the impacts of miR‐204‐3p on cell growth, migration, invasion, and their associated factors through assessment of CCK‐8, flow cytometry, Transwell, and western blot, respectively. High mobility group AT‐hook 2 (HMGA2) expression was then detected in Caco‐2 cells after miR‐204‐3p mimic and inhibitor transfection, additionally dual‐luciferase activity was implemented to further uncover the correlation between HMGA2 and miR‐204‐3p. The impact of HMGA2 on Caco‐2 cell growth, migration, and invasion was finally assessed. We found that repression of miR‐204‐3p was discovered in colon cancer tissues and HCT116, SW480, Caco‐2, HT29 and SW620 cell lines. MiR‐204‐3p overexpression mitigated Coca‐2 cell viability, facilitated apoptosis, simultaneously adjusted CyclinD1 and cleaved caspase‐3 expression. Cell migration, invasion, and the associated factors were all suppressed by miR‐204‐3p overexpression. Reduction of HMGA2 was presented in Caco‐2 cells with miR‐204‐3p mimic transfection, and HMGA2 was predicated to be a target gene of miR‐204‐3p. Besides, HMGA2 silence showed the inhibitory effect on Caco‐2 cells growth, migration, and invasion. In conclusion, miR‐204‐3p repressed colon cancer cell growth, migration, and invasion through targeting HMGA2.