Relationship between subjective and objective cognitive functionin the early and late prodrome

BackgroundCognitive disturbances have been demonstrated in individuals withpotentially prodromal symptoms in objective–neuropsychological as well assubjective-symptomatic studies. Yet, the relation between subjective andobjective deficits and to different prodromal states is unclearAimsTo explore interactions between subjective and objective cognitivemeasures in different prodromal statesMethodIn participants with an early (n=33) or late(n=69) initial prodromal state, cognitive subjectiveand objective deficits were assessed with the Schizophrenia PronenessInstrument and a comprehensive neuropsychological test batteryResultsParticipants with an early initial prodromal state were less impairedthan those with a late initial state. Subjective and objective cognitivedeficits were unrelated, excepttime-limited neurocognitive speed measuresand subjectively reduced stress tolerance, especially in participantswith an early initial prodromal stateConclusionsSubjective and objective cognitive deficits are generally unrelated inthe psychosis prodrome and as such they can add complementary informationvaluable for prediction. However, possible associations between the twolevels might be better detectable in the less impaired early initialprodromal state