Electrospun, drug-enriched bioresorbable nonwovens based on poly(glycolide-ɛ-caprolactone) and poly(d,l-lactide-glycolide) for urological applications

Nonwoven polymeric materials for urological applications have been prepared from different kinds of polymers: poly(glycolide-ɛ-caprolactone) (PGCL) and poly(d,l-lactide-co-glycolide) (PLGA) with the use of electrospinning technique. In order to modify properties of the electrospun nonwovens, the mixture of PGCL and PLGA have been additionally prepared. The aim of this modification was to obtain materials with intermediated properties. Additionally, diastolic drug was incorporated into the polymeric matrix in order to achieve enhanced functionality. It appeared that selected copolymers enriched with diastolic drug possess excellent fiber-forming ability. Moreover, by this incorporation, drug delivery systems for local administration for urological purposes have been obtained. The idea of local administration of a drug is highly desirable. It provides the possibility of reducing the drug dose and might enhance the efficiency of the therapy. For all nonwoven materials burst release of papaverine was observed, what was desired and expected result. This study is based on our experience with various drug delivery systems intended for different therapies. The obtained results indicate high potential of the developed polyester-based nonwovens for urological applications and local release of incorporated drug. As the possibility of designing proper, nonwoven, polyester-based materials have been confirmed, it is planned to expand range of incorporated drugs, so as to obtain various biodegradable systems for urological applications. •Biodegradable, dressing-like and tube-shaped nonwovens have been developed for urological applications.•Electrospinning technique has been used since PGCL and PLGA are good fiber-forming materials.•Nonwovens were enriched with papaverine for local administration and in order to achieve enhanced functionality.