The effects of ingesting coffee chlorogenic acid on peripheral skin temperature and skin blood flow after a cold stress test: A randomized, double-blind, placebo-controlled, crossover study

Chlorogenic acids (CGA), the major compound of coffee polyphenols, show an anti-hypertension activity in an endothelium dependent manner. In this study, we investigated the effects of ingesting CGA on peripheral skin temperature (SkT) and skin blood flow (SkBF) after a cold stress test. A double-blind, randomized, placebo-controlled, crossover intervention study was conducted on Japanese healthy women. A cold stress (water temperature of 15°C, 1 min) test was performed on both hands of each subject 50 minutes after ingesting 270 mg of CGA and placebo with 1 week washout period. SkT and SkBF were then measured simultaneously before the cold stress and at 2.5-minute intervals for 30 minutes after cold stress test. Twenty-four subjects were enrolled and ramdomized into two groups. Twenty-one of these subjects completed this study. Significant improvement of the recovery of SkT and SkBF after the cold stress test were observed in CGA compared with placebo. These findings suggested that the ingestion of CGA improves SkT and SkBF after cold stress.