Lactate links metabolism to genes

During glycolysis, glucose is converted into two pyruvate molecules; these can be either funnelled into lactate production or transported into the cellular power generators (the mitochondria), forming the intermediate acetyl coenzyme A (acetylCoA) and thence entering the Krebs cycle for energy produ...

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Veröffentlicht in:Nature (London) 2019-10, Vol.574 (7779), p.492-493
Hauptverfasser: Izzo, Luke T, Wellen, Kathryn E
Format: Artikel
Sprache:eng
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Zusammenfassung:During glycolysis, glucose is converted into two pyruvate molecules; these can be either funnelled into lactate production or transported into the cellular power generators (the mitochondria), forming the intermediate acetyl coenzyme A (acetylCoA) and thence entering the Krebs cycle for energy production. The authors also compared lysine lactylation and acetylation, finding lactylation at many genes that lack acetylation - suggesting distinct roles for the two modifications. [...]macrophages that could not produce lactate could increase the expression of inflammatory genes in response to stimulation with LPS, but could not upregulate lysine lactylation or the associated expression of homeostatic genes at later times. Luke T. Izzo and Kathryn E. Wellen are In the Department of Cancer Biology and Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. e-mail: wellenk@upenn.edu "The findings raise questions about the biochemistry of lactylation and its broader roles in physiology and disease."
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-019-03122-1