PIDA-mediated α-C–H functionalization of enaminones: the synthesis of thiocyano enaminones and chromones in water
Herein, an efficient, metal-free process for the α-C–H thiocyanation of enaminones was developed using PhI(OAc) 2 as an oxidant at room temperature in an aqueous medium. Various SCN-containing enaminones and chromones with broad functional groups were synthesized in moderate to good yields in the pr...
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Veröffentlicht in: | New journal of chemistry 2019, Vol.43 (42), p.16441-16444 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Herein, an efficient, metal-free process for the α-C–H thiocyanation of enaminones was developed using PhI(OAc)
2
as an oxidant at room temperature in an aqueous medium. Various SCN-containing enaminones and chromones with broad functional groups were synthesized in moderate to good yields in the presence of KSCN. In addition, 3-selenocyanochromone was synthesized using this fast, green, metal-free approach. |
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ISSN: | 1144-0546 1369-9261 |
DOI: | 10.1039/C9NJ04580E |