Synthesis and Properties of Aminomethoxy Derivatives of 1-Phenoxy-3-(propylsulfanyl)propane

Synthesis and Properties of Aminomethoxy Derivatives of 1-Phenoxy-3-(propylsulfanyl)propane

The condensation of 1-phenoxy-3-(propylsulfanyl)propan-2-ol with formaldehyde and secondary aliphatic and heterocyclic amines afforded new aminomethoxy derivatives of 1-phenoxy-3-(propylsulfanyl)- propane in 69–77% yields. The product structure was confirmed by elemental analyses and IR and 1 H and...

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Veröffentlicht in:Russian journal of organic chemistry 2019-09, Vol.55 (9), p.1275-1279
Hauptverfasser: Jafarov, I. A., Mammadbayli, E. H., Kochetkov, K. A., Astanova, A. D., Maharramova, L. M.
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Amines
Antiseptics
Chemistry
Chemistry and Materials Science
Condensates
Derivatives
Heterocyclic amines
NMR
Nuclear magnetic resonance
Organic Chemistry
Propane
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Zusammenfassung:The condensation of 1-phenoxy-3-(propylsulfanyl)propan-2-ol with formaldehyde and secondary aliphatic and heterocyclic amines afforded new aminomethoxy derivatives of 1-phenoxy-3-(propylsulfanyl)- propane in 69–77% yields. The product structure was confirmed by elemental analyses and IR and 1 H and 13 C NMR spectra. The synthesized compounds were assayed as antiseptics against bacteria and fungi and were shown to be more efficient antimicrobial agents than those currently used in medicine.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019090021