A Chemical Photo‐Oxidation of 5‐Methyl Cytidines

A Chemical Photo‐Oxidation of 5‐Methyl Cytidines

A new approach for the oxidation of 5‐methyl cytidine modification in nucleic acids to 5‐formyl cytidine is reported. This method displays excellent chemo‐/bio‐ selectivity, from which the methyl group in cytidine nucleosides could be selectively oxidized to biologically important formyl functionali...

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Veröffentlicht in:Advanced synthesis & catalysis 2019-10, Vol.361 (20), p.4685-4690
Hauptverfasser: Jin, Xiao‐Yang, Wang, Rui‐Li, Xie, Li‐Jun, Kong, De‐Long, Liu, Li, Cheng, Liang
Format: Artikel
Sprache:eng
Schlagworte:
5-formylcytidine
5-methylcytidine
artificial enzymes
Biomolecules
epigenetic modifications
Nucleic acids
Organic chemistry
Oxidation
photochemical oxidation
Selectivity
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Zusammenfassung:A new approach for the oxidation of 5‐methyl cytidine modification in nucleic acids to 5‐formyl cytidine is reported. This method displays excellent chemo‐/bio‐ selectivity, from which the methyl group in cytidine nucleosides could be selectively oxidized to biologically important formyl functionality without interfering with other cellular biomolecules.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201900811