Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression

Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression

Eukaryotic translation elongation factor 1A exists as two 98 % homologous isoforms: eEF1A1 (A1) and eEF1A2 (A2) which are tissue and development specific. Despite high homology in an open reading frame (ORF) region, mRNAs coding for eEF1A1 and eEF1A2 are different in their untranslated regions (UTR)...

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Veröffentlicht in:Biopolimery i kletka 2013, Vol.29 (1), p.55-63
Hauptverfasser: Vislovukh, A. A., Naumovets, M. G., Kovalenko, M. I., Groisman, R. S., Groisman, I. S., Negrutskii, B. S., El'skaya, A. V.
Format: Artikel
Sprache:eng
Schlagworte:
Breast cancer
Gene regulation
Homology
Isoforms
Open reading frames
Post-transcription
Translation elongation
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Zusammenfassung:Eukaryotic translation elongation factor 1A exists as two 98 % homologous isoforms: eEF1A1 (A1) and eEF1A2 (A2) which are tissue and development specific. Despite high homology in an open reading frame (ORF) region, mRNAs coding for eEF1A1 and eEF1A2 are different in their untranslated regions (UTR), suggesting a possibility of their dissimilar post-transcriptional regulation.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000806