Antiviral activity of trimeric 2',5'-oligoadenylic acid and some of its analogues

The authors have studied the antiviral effect of 2',5'-trioligoadenylate and of its derivatives using several model cell culture systems and viruses: L929 murinc fibroblast cells infected by vaccine virus, established testicular piglet cells inoculated by Aueszki disease virus (ADV) (strai...

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Veröffentlicht in:Biopolimery i kletka 1995-09, Vol.11 (5), p.56-60
Hauptverfasser: Tkachuk, Z. Yu, Semernikova, L. I., Tkachuk, V. V., Reshotko, L. M., Mikhailopulo, I. A., Matsuka, G. Kh
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Sprache:eng
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Zusammenfassung:The authors have studied the antiviral effect of 2',5'-trioligoadenylate and of its derivatives using several model cell culture systems and viruses: L929 murinc fibroblast cells infected by vaccine virus, established testicular piglet cells inoculated by Aueszki disease virus (ADV) (strain BUK-628), and the same culture infected with Purdue-115 strain (reference strains of transmissible gastroenteritis virus (TGEV)). So, it is possible to suppose that both 2',5'-trioligoadenylate and its derivative are perspective antiviral preparations acting against DNA- and RNA-containing viruses.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.0003FC