Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd–Cu

Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd–Cu

An efficient method is developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature. Excellent yi...

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Veröffentlicht in:Journal of chemical research 2019-09, Vol.43 (9-10), p.431-436
Hauptverfasser: Rezaeimanesh, Fatemeh, Bakherad, Mohammad, Nasr-Isfahani, Hossein
Format: Artikel
Sprache:eng
Schlagworte:
Acetonitrile
Aromatic compounds
Carbon
Chemical reactions
Chemical synthesis
Iodides
Palladium
Pyrimidines
Solvents
Temperature
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Beschreibung
Zusammenfassung:An efficient method is developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature. Excellent yields of the products were obtained in reaction times of 9–11 h.
ISSN:1747-5198
2047-6507
DOI:10.1177/1747519819868920