32 Prevalence and characteristics of non –lipid risk factors in familial hypercholesterolaemia – a study based in the population registered in the latvian registry of familial hypercholesterolaemia

BackgroundFamilial Hypercholesterolaemia (FH) is characterized by extremely high low density lipoprotein-cholesterol (LDL-C) concentration, which subsequently increases the risk greatly, for the development of premature cardiovascular disease (CVD). In addition to (LDL-C) other non-lipid risk factors play an important role in the increase of premature-CVD, therefore it is important to be tackled during lifetime or from childhood. Aim: The aim of the present study is to determine and identify the non-lipid risk factors that may contribute to CVD in FH patients.Materials and methodsThis is a retrospective analysis of a cohort of patients with probable or definite FH diagnosis, registered at the Latvian Registry of Familial Hypercholesterolaemia (LRFH) in Riga Latvia. Patients were evaluated for hypertension (>140/90 mmHg), diabetes mellitus (DM), smoking history, body mass index (BMI) (overweight-BMI >25 kg/m2 or obesity-BMI >30 kgm2). Dietary habits of the patients were interviewed according to PREDIMED questionnaire (score range 0 to 13), moderate physical activity of (2,5 hours/week) and high intensity of (1,5 hours/week) self-reported from patients and family history of premature CHD.ResultsA total of 170 patients (n=130 index cases and n=40 first degree relatives), (n=110) having history of CVD (table 1). Mean age of the patients with history of CVD was (56.2±10.7) years. Hypertension was present in 77 (48.1%), DM was seen in 8 (4.7%), smoking history was observed in 29 (22.7%) with a mean pack of years (15.3±11.6). Overweight and obesity was diagnosed in 39 (22.9%) and 49 (28.8%), respectively. Mean BMI (kg/m2) was significantly higher in patients with CVD in comparison to patients without CVD, (28.8±3.25vs.27.2±4.75, respectively, p=0.013). Mean PREDIMED score was (5.8±2.5). Moderate physical activity was observed in 78 (45.9%) and high intensity in 39 (22.9%) patients. Family history of premature CHD was positive in 88 (51.8%) with 46 (73.0%) that had evidence of CVD. From the multivariate analysis hypertension was a significant and independent risk factor for CVD with odds ratio (OR) (7.451). (table 2).Abstract 32 Table 1Characteristics of the entire cohort stratified by presence or absence of cardiovascular disease Characteristics of the entire cohort stratified by presence or absence of cardiovascular diseaseAbstract 32 Table 2Laboratory results of the entire cohort at patients first visit at the hospital Laboratory results of the entire cohort at