Histogenesis Stages of Osteogenic Grafts in Culture Medium and a Recipient Bed

— This paper describes the stages of osteogenic differentiation of chondrogenic graft in a culture medium and recipient bed (defect of bone tissue). In the culture medium, cell and matrix transformations, formation of vascular cavities with an endothelial lining and matrix vesicles in osteoblasts (the first stage of mineralization) take place in the chondrograft. The expression of chondrogenic genes and proteins is replaced by the expression of genes and proteins of the osteogenic stage of differentiation. Further stages of bone tissue histogenesis occur in the recipient bed. Humoral factors of regulation and ductile substance enter through the formed anastomosis of the vessels of osteodysplastica and recipient. On their basis, the formation of an organ-specific regenerate is completed with full integration into the recipient organism. These results are a starting point for further use of osteogenic grafts in clinical practice.