Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans
The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin p...
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description | The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin propionate ester (propionate bound to inulin through an ester linkage) significantly increases the postprandial release of GLP-1 and PYY, whilst significantly decreasing food intake (unpublished findings). The time to 50% AUC excretion of 13C in breath (T1/2), a proxy for gastric emptying rate, was not significantly different between acute propionate ester and control trials (T1/2 180 min [95% CI, 163 to 198] control vs. 185 min [95% CI, 168 to 204] control, P = 0.51).These data demonstrate that acute ingestion of 10 g of inulin propionate ester increases satiety and reduces appetite in humans but this is not through an effect on gastric emptying, and it is most likely to be a centrally mediated action of GLP-1 and PYY. 1. |
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The time to 50% AUC excretion of 13C in breath (T1/2), a proxy for gastric emptying rate, was not significantly different between acute propionate ester and control trials (T1/2 180 min [95% CI, 163 to 198] control vs. 185 min [95% CI, 168 to 204] control, P = 0.51).These data demonstrate that acute ingestion of 10 g of inulin propionate ester increases satiety and reduces appetite in humans but this is not through an effect on gastric emptying, and it is most likely to be a centrally mediated action of GLP-1 and PYY. 1.</description><identifier>ISSN: 0029-6651</identifier><identifier>EISSN: 1475-2719</identifier><identifier>DOI: 10.1017/S0029665114000354</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Appetite ; Colon ; Dietary supplements ; Emptying ; Fatty acids ; Food intake ; Gastric emptying ; Glucagon ; Hormones ; Ingestion ; Inulin ; Menopause ; Peptides ; Propionic acid ; Receptors ; Satiety</subject><ispartof>Proceedings of the Nutrition Society, 2014, Vol.73 (OCE1), Article E21</ispartof><rights>Copyright © The Authors 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2054-d9cb3bb87f05bfd39fb08206d59ec4f7ce736f8c82e60bc1fc3e8fe949265ef83</citedby><cites>FETCH-LOGICAL-c2054-d9cb3bb87f05bfd39fb08206d59ec4f7ce736f8c82e60bc1fc3e8fe949265ef83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0029665114000354/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,4024,27923,27924,27925,55628</link.rule.ids></links><search><creatorcontrib>Alhabeeb, H.</creatorcontrib><creatorcontrib>Chambers, E. S.</creatorcontrib><creatorcontrib>Frost, G.</creatorcontrib><creatorcontrib>Morrison, D. J.</creatorcontrib><creatorcontrib>Preston, T.</creatorcontrib><title>Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans</title><title>Proceedings of the Nutrition Society</title><addtitle>Proc. Nutr. Soc</addtitle><description>The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin propionate ester (propionate bound to inulin through an ester linkage) significantly increases the postprandial release of GLP-1 and PYY, whilst significantly decreasing food intake (unpublished findings). The time to 50% AUC excretion of 13C in breath (T1/2), a proxy for gastric emptying rate, was not significantly different between acute propionate ester and control trials (T1/2 180 min [95% CI, 163 to 198] control vs. 185 min [95% CI, 168 to 204] control, P = 0.51).These data demonstrate that acute ingestion of 10 g of inulin propionate ester increases satiety and reduces appetite in humans but this is not through an effect on gastric emptying, and it is most likely to be a centrally mediated action of GLP-1 and PYY. 1.</description><subject>Appetite</subject><subject>Colon</subject><subject>Dietary supplements</subject><subject>Emptying</subject><subject>Fatty acids</subject><subject>Food intake</subject><subject>Gastric emptying</subject><subject>Glucagon</subject><subject>Hormones</subject><subject>Ingestion</subject><subject>Inulin</subject><subject>Menopause</subject><subject>Peptides</subject><subject>Propionic acid</subject><subject>Receptors</subject><subject>Satiety</subject><issn>0029-6651</issn><issn>1475-2719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1UF1LwzAUDaLgnP4A3wI-V2-aNm0fZfgxGPigPpckvdkytrQmKdJ_b4YTH8SnC-frcg4h1wxuGbDq7hUgb4QoGSsAgJfFCZmxoiqzvGLNKZkd6OzAn5OLELYATBS1mJHPpRt31tHB94PtnYxIMUT01DrtUQYMNMhoMU5Uuo52-IPKYcBok1yNkXZ9QlwfqTQGdaRrGaK3muJ-iJN165RGNyh3cTPRzbiXLlySMyN3Aa-Od07eHx_eFs_Z6uVpubhfZTqHssi6RiuuVF0ZKJXpeGMU1DmIrmxQF6bSWHFhal3nKEBpZjTH2mBTNLko0dR8Tm6-c1PBjzFVa7f96F162eYcBEs6AUnFvlXa9yF4NO3g7V76qWXQHvZt_-ybPPzokXvlbbfG3-j_XV9B_X9M</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Alhabeeb, H.</creator><creator>Chambers, E. 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S.</au><au>Frost, G.</au><au>Morrison, D. J.</au><au>Preston, T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans</atitle><jtitle>Proceedings of the Nutrition Society</jtitle><addtitle>Proc. Nutr. Soc</addtitle><date>2014</date><risdate>2014</risdate><volume>73</volume><issue>OCE1</issue><artnum>E21</artnum><issn>0029-6651</issn><eissn>1475-2719</eissn><abstract>The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin propionate ester (propionate bound to inulin through an ester linkage) significantly increases the postprandial release of GLP-1 and PYY, whilst significantly decreasing food intake (unpublished findings). The time to 50% AUC excretion of 13C in breath (T1/2), a proxy for gastric emptying rate, was not significantly different between acute propionate ester and control trials (T1/2 180 min [95% CI, 163 to 198] control vs. 185 min [95% CI, 168 to 204] control, P = 0.51).These data demonstrate that acute ingestion of 10 g of inulin propionate ester increases satiety and reduces appetite in humans but this is not through an effect on gastric emptying, and it is most likely to be a centrally mediated action of GLP-1 and PYY. 1.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><doi>10.1017/S0029665114000354</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Appetite Colon Dietary supplements Emptying Fatty acids Food intake Gastric emptying Glucagon Hormones Ingestion Inulin Menopause Peptides Propionic acid Receptors Satiety |
title | Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans |
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