Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans

The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin p...

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Veröffentlicht in:Proceedings of the Nutrition Society 2014, Vol.73 (OCE1), Article E21
Hauptverfasser: Alhabeeb, H., Chambers, E. S., Frost, G., Morrison, D. J., Preston, T.
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creator Alhabeeb, H.
Chambers, E. S.
Frost, G.
Morrison, D. J.
Preston, T.
description The short chain fatty acid (SCFA) propionate stimulates free fatty acid receptors 2 and 3 (FFAR2, FFAR3) found on enteroendocrine L-cells and increases the release of the anorectic gut hormones glucagon like-peptide-1(GLP-1) and peptide YY (PYY) in vitro (1). Dietary supplementation with an inulin propionate ester (propionate bound to inulin through an ester linkage) significantly increases the postprandial release of GLP-1 and PYY, whilst significantly decreasing food intake (unpublished findings). The time to 50% AUC excretion of 13C in breath (T1/2), a proxy for gastric emptying rate, was not significantly different between acute propionate ester and control trials (T1/2 180 min [95% CI, 163 to 198] control vs. 185 min [95% CI, 168 to 204] control, P = 0.51).These data demonstrate that acute ingestion of 10 g of inulin propionate ester increases satiety and reduces appetite in humans but this is not through an effect on gastric emptying, and it is most likely to be a centrally mediated action of GLP-1 and PYY. 1.
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subjects Appetite
Colon
Dietary supplements
Emptying
Fatty acids
Food intake
Gastric emptying
Glucagon
Hormones
Ingestion
Inulin
Menopause
Peptides
Propionic acid
Receptors
Satiety
title Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans
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