Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study
Background This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases. Methods A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) an...
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| Veröffentlicht in: | Head & neck 2019-11, Vol.41 (11), p.3826-3832 |
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| creator | Hasmat, Shaheen Ebrahimi, Ardalan Luk, Peter P. Low, Tsu‐Hui (Hubert) McDowell, Lachlan Magarey, Matthew J. R. Veness, Michael Gupta, Ruta Clark, Jonathan |
| description | Background
This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases.
Methods
A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression.
Results
Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%‐31.7%; P |
| doi_str_mv | 10.1002/hed.25912 |
| format | Article |
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This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases.
Methods
A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression.
Results
Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%‐31.7%; P < .001) and immunosuppression (1.9%‐9.9%; P = .03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer‐related mortality from 0.47 in 1990‐1999 (P = .04) to 0.30 in 2000‐2009 (P < .001) when compared to 1980‐1989. This remained stable at 0.30 in 2010‐2017 (P = .001). OS remained stable after 1990.
Conclusion
Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25912</identifier><identifier>PMID: 31407466</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aging ; carcinoma ; chemoradiation ; Head & neck cancer ; Head and neck ; Immunosuppression ; Lymph nodes ; Metastases ; Metastasis ; Neck ; Skin cancer ; Squamous cell carcinoma ; surgery ; survival</subject><ispartof>Head & neck, 2019-11, Vol.41 (11), p.3826-3832</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3882-b466d4b54c5e3d7678a9262c50daa3c1e59ecf0f2c59df576ae9a26bf8e8b6133</citedby><cites>FETCH-LOGICAL-c3882-b466d4b54c5e3d7678a9262c50daa3c1e59ecf0f2c59df576ae9a26bf8e8b6133</cites><orcidid>0000-0001-8958-736X ; 0000-0002-5170-787X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25912$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25912$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31407466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasmat, Shaheen</creatorcontrib><creatorcontrib>Ebrahimi, Ardalan</creatorcontrib><creatorcontrib>Luk, Peter P.</creatorcontrib><creatorcontrib>Low, Tsu‐Hui (Hubert)</creatorcontrib><creatorcontrib>McDowell, Lachlan</creatorcontrib><creatorcontrib>Magarey, Matthew J. R.</creatorcontrib><creatorcontrib>Veness, Michael</creatorcontrib><creatorcontrib>Gupta, Ruta</creatorcontrib><creatorcontrib>Clark, Jonathan</creatorcontrib><title>Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases.
Methods
A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression.
Results
Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%‐31.7%; P < .001) and immunosuppression (1.9%‐9.9%; P = .03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer‐related mortality from 0.47 in 1990‐1999 (P = .04) to 0.30 in 2000‐2009 (P < .001) when compared to 1980‐1989. This remained stable at 0.30 in 2010‐2017 (P = .001). OS remained stable after 1990.
Conclusion
Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.</description><subject>Aging</subject><subject>carcinoma</subject><subject>chemoradiation</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>Immunosuppression</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neck</subject><subject>Skin cancer</subject><subject>Squamous cell carcinoma</subject><subject>surgery</subject><subject>survival</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EouWx4AeQJVYsQh07cRJ2iLdUBAtYRxN7IgJ5tH4UVWLBJ_CNfAkuhSUrj-4cHY8uIQcxO4kZ45Nn1Cc8LWK-QcYxK7KIiSTbXM2JiATLkhHZsfaFMSZkwrfJSMRJSKUck_eHwTauWSC13iyaBbTUGew1bXraoQPrwDWKPiNoCiHuUb1S5R30OHhL7dxDtxoUti1VYFTTDx3QYYGG1oM3Xx-fGhVotKf0zrfBhb0LO-u8Xu6RrRpai_u_7y55urp8PL-JpvfXt-dn00iJPOdRFS7VSZUmKkWhM5nlUHDJVco0gFAxpgWqmtUhKXSdZhKwAC6rOse8krEQu-Ro7Z2ZYe7RuvIlnNaHL0suWJowzpkM1PGaUmaw1mBdzkzTgVmWMStXPZeh5_Kn58Ae_hp91YX0j_wrNgCTNfDWtLj831TeXF6sld8nwopV</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Hasmat, Shaheen</creator><creator>Ebrahimi, Ardalan</creator><creator>Luk, Peter P.</creator><creator>Low, Tsu‐Hui (Hubert)</creator><creator>McDowell, Lachlan</creator><creator>Magarey, Matthew J. R.</creator><creator>Veness, Michael</creator><creator>Gupta, Ruta</creator><creator>Clark, Jonathan</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-8958-736X</orcidid><orcidid>https://orcid.org/0000-0002-5170-787X</orcidid></search><sort><creationdate>201911</creationdate><title>Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study</title><author>Hasmat, Shaheen ; Ebrahimi, Ardalan ; Luk, Peter P. ; Low, Tsu‐Hui (Hubert) ; McDowell, Lachlan ; Magarey, Matthew J. R. ; Veness, Michael ; Gupta, Ruta ; Clark, Jonathan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3882-b466d4b54c5e3d7678a9262c50daa3c1e59ecf0f2c59df576ae9a26bf8e8b6133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aging</topic><topic>carcinoma</topic><topic>chemoradiation</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>Immunosuppression</topic><topic>Lymph nodes</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neck</topic><topic>Skin cancer</topic><topic>Squamous cell carcinoma</topic><topic>surgery</topic><topic>survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasmat, Shaheen</creatorcontrib><creatorcontrib>Ebrahimi, Ardalan</creatorcontrib><creatorcontrib>Luk, Peter P.</creatorcontrib><creatorcontrib>Low, Tsu‐Hui (Hubert)</creatorcontrib><creatorcontrib>McDowell, Lachlan</creatorcontrib><creatorcontrib>Magarey, Matthew J. R.</creatorcontrib><creatorcontrib>Veness, Michael</creatorcontrib><creatorcontrib>Gupta, Ruta</creatorcontrib><creatorcontrib>Clark, Jonathan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasmat, Shaheen</au><au>Ebrahimi, Ardalan</au><au>Luk, Peter P.</au><au>Low, Tsu‐Hui (Hubert)</au><au>McDowell, Lachlan</au><au>Magarey, Matthew J. R.</au><au>Veness, Michael</au><au>Gupta, Ruta</au><au>Clark, Jonathan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2019-11</date><risdate>2019</risdate><volume>41</volume><issue>11</issue><spage>3826</spage><epage>3832</epage><pages>3826-3832</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
This study assessed changes over time of survival of head and neck cutaneous squamous cell carcinoma (HNcSCC) with lymph node metastases.
Methods
A multicenter analysis of 1301 patients with metastatic HNcSCC treated between 1980 and 2017. Differences in disease‐specific survival (DSS) and overall survival (OS) by decade were assessed using multivariate Cox regression.
Results
Over the study period, we noted an increase in the proportion of patients aged over 80 years (3.9%‐31.7%; P < .001) and immunosuppression (1.9%‐9.9%; P = .03). After adjusting for number and size of metastatic nodes, extranodal extension, perineural invasion, immunosuppression, treatment, and institution, there was a reduction in risk of cancer‐related mortality from 0.47 in 1990‐1999 (P = .04) to 0.30 in 2000‐2009 (P < .001) when compared to 1980‐1989. This remained stable at 0.30 in 2010‐2017 (P = .001). OS remained stable after 1990.
Conclusion
Despite an aging and more frequently immunosuppressed population, fewer patients are dying from metastatic HNcSCC.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31407466</pmid><doi>10.1002/hed.25912</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8958-736X</orcidid><orcidid>https://orcid.org/0000-0002-5170-787X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Aging carcinoma chemoradiation Head & neck cancer Head and neck Immunosuppression Lymph nodes Metastases Metastasis Neck Skin cancer Squamous cell carcinoma surgery survival |
| title | Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: Multicenter study |
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