Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial)

The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose ranges for reduction of low-density lipoprotein (LDL) cholesterol. Secondary objectives included comparing rosuvasta...

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Veröffentlicht in:	The American journal of cardiology 2003-07, Vol.92 (2), p.152-160
Hauptverfasser:	Jones, Peter H, Davidson, Michael H, Stein, Evan A, Bays, Harold E, McKenney, James M, Miller, Elinor, Cain, Valerie A, Blasetto, James W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Atorvastatin Biological and medical sciences Cholesterol, LDL - blood Cholesterol, LDL - drug effects Comparative analysis Dose-Response Relationship, Drug Drug therapy Female Fluorobenzenes - administration & dosage Fluorobenzenes - adverse effects Fluorobenzenes - therapeutic use General and cellular metabolism. Vitamins Heptanoic Acids - administration & dosage Heptanoic Acids - adverse effects Heptanoic Acids - therapeutic use Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Male Medical sciences Middle Aged Pharmacology. Drug treatments Pravastatin - administration & dosage Pravastatin - adverse effects Pravastatin - therapeutic use Pyrimidines Pyrroles - administration & dosage Pyrroles - adverse effects Pyrroles - therapeutic use Rosuvastatin Calcium Safety Simvastatin - administration & dosage Simvastatin - adverse effects Simvastatin - therapeutic use Sulfonamides Time Factors
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Beschreibung
Zusammenfassung:	The primary objective of this 6-week, parallel-group, open-label, randomized, multicenter trial was to compare rosuvastatin with atorvastatin, pravastatin, and simvastatin across dose ranges for reduction of low-density lipoprotein (LDL) cholesterol. Secondary objectives included comparing rosuvastatin with comparators for other lipid modifications and achievement of National Cholesterol Education Program Adult Treatment Panel III and Joint European Task Force LDL cholesterol goals. After a dietary lead-in period, 2,431 adults with hypercholesterolemia (LDL cholesterol ≥160 and
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(03)00530-7