Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential
This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. These results suggest that beta blockade blunts...
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Veröffentlicht in: | The American journal of cardiology 2000-12, Vol.86 (12), p.1398-1400 |
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creator | Fernhall, Bo Szymanski, Linda M Gorman, Patrick A Kamimori, Gary H Kessler, Craig M |
description | This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. These results suggest that beta blockade blunts the fibrinolytic response to maximal exercise. |
doi_str_mv | 10.1016/S0002-9149(00)01242-X |
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Drug treatments</topic><topic>Physical Exertion - physiology</topic><topic>Placebos</topic><topic>Plasminogen Activator Inhibitor 1 - blood</topic><topic>Propranolol - pharmacology</topic><topic>Rest - physiology</topic><topic>Serine Proteinase Inhibitors - blood</topic><topic>Tissue Plasminogen Activator - antagonists & inhibitors</topic><topic>Tissue Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernhall, Bo</creatorcontrib><creatorcontrib>Szymanski, Linda M</creatorcontrib><creatorcontrib>Gorman, Patrick A</creatorcontrib><creatorcontrib>Kamimori, Gary H</creatorcontrib><creatorcontrib>Kessler, Craig M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernhall, Bo</au><au>Szymanski, Linda M</au><au>Gorman, Patrick A</au><au>Kamimori, Gary H</au><au>Kessler, Craig M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2000-12-15</date><risdate>2000</risdate><volume>86</volume><issue>12</issue><spage>1398</spage><epage>1400</epage><pages>1398-1400</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. 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subjects | Adrenergic beta-Antagonists - pharmacology Adult Analysis of Variance Antifibrinolytic Agents - pharmacology Atenolol - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiology Cardiovascular system Cross-Over Studies Double-Blind Method Drug Interactions Drug therapy Exercise Fibrinolytic Agents - blood Heart Heart Rate - drug effects Humans Male Medical sciences Miscellaneous Pharmacology. Drug treatments Physical Exertion - physiology Placebos Plasminogen Activator Inhibitor 1 - blood Propranolol - pharmacology Rest - physiology Serine Proteinase Inhibitors - blood Tissue Plasminogen Activator - antagonists & inhibitors Tissue Plasminogen Activator - blood |
title | Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential |
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