Both atenolol and propranolol blunt the fibrinolytic response to exercise but not resting fibrinolytic potential

This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. These results suggest that beta blockade blunts...

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Veröffentlicht in:	The American journal of cardiology 2000-12, Vol.86 (12), p.1398-1400
Hauptverfasser:	Fernhall, Bo, Szymanski, Linda M, Gorman, Patrick A, Kamimori, Gary H, Kessler, Craig M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Adult Analysis of Variance Antifibrinolytic Agents - pharmacology Atenolol - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiology Cardiovascular system Cross-Over Studies Double-Blind Method Drug Interactions Drug therapy Exercise Fibrinolytic Agents - blood Heart Heart Rate - drug effects Humans Male Medical sciences Miscellaneous Pharmacology. Drug treatments Physical Exertion - physiology Placebos Plasminogen Activator Inhibitor 1 - blood Propranolol - pharmacology Rest - physiology Serine Proteinase Inhibitors - blood Tissue Plasminogen Activator - antagonists & inhibitors Tissue Plasminogen Activator - blood
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Zusammenfassung:	This randomized, double-blind trial found that tissue plasminogen activator activity increased and plasminogen activator inhibitor-1 activity decreased significantly more with exercise during placebo treatment than during treatment with beta blockade. These results suggest that beta blockade blunts the fibrinolytic response to maximal exercise.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(00)01242-X