Protection from digoxin-induced coronary vasoconstriction in patients with coronary artery disease by calcium antagonists

Intravenous digoxin induces constriction of normal and stenotic coronary arteries in patients with coronary artery disease, which may lead to ischemic complications. We found that pretreatment with oral nisoldipine and intracoronary nitroglycerin neutralizes this digoxin-induced effect.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of cardiology 1999-02, Vol.83 (3), p.440-442
Hauptverfasser:	Nolte, Carsten W.T, Jost, Stefan, Mügge, Andreas, Daniel, Werner G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyldigoxins - adverse effects Biological and medical sciences Calcium Calcium Channel Blockers - therapeutic use Cardiology Cardiotonic Agents - adverse effects Cardiovascular disease Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - drug therapy Coronary Vasospasm - chemically induced Coronary Vasospasm - diagnostic imaging Coronary Vasospasm - prevention & control Drug therapy Drug toxicity and drugs side effects treatment Female Follow-Up Studies Humans Male Medical sciences Middle Aged Nisoldipine - therapeutic use Nitroglycerin - therapeutic use Pharmacology. Drug treatments Toxicity: cardiovascular system Treatment Outcome Vasoconstriction - drug effects Vasodilator Agents - therapeutic use
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Intravenous digoxin induces constriction of normal and stenotic coronary arteries in patients with coronary artery disease, which may lead to ischemic complications. We found that pretreatment with oral nisoldipine and intracoronary nitroglycerin neutralizes this digoxin-induced effect.
ISSN:	0002-9149 1879-1913
DOI:	10.1016/S0002-9149(98)00881-9