Differential effects of UTP, ATP, and adenosine on ciliary activity of human nasal epithelial cells

The purinergic regulation of ciliary activity was studied using small, continuously superfused explants of human nasal epithelium. The P2Y2 purinoceptor (P2Y2-R) was identified as the major purinoceptor regulating ciliary beat frequency (CBF); UTP (EC50=4.7 muM), ATP, and adenosine-5'-O-(3-thio...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-06, Vol.49 (6), p.1485-1497
Hauptverfasser:	MORSE, Diane M, SMULLEN, Jennifer L, DAVIS, C. William
Format:	Artikel
Sprache:	eng
Schlagworte:	Air breathing Biological and medical sciences Cellular biology Drugs Experiments Fundamental and applied biological sciences. Psychology Medical research Respiratory system Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Vertebrates: respiratory system
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Zusammenfassung:	The purinergic regulation of ciliary activity was studied using small, continuously superfused explants of human nasal epithelium. The P2Y2 purinoceptor (P2Y2-R) was identified as the major purinoceptor regulating ciliary beat frequency (CBF); UTP (EC50=4.7 muM), ATP, and adenosine-5'-O-(3-thiotriphosphate) elicited similar maximal responses, approximately twofold over baseline.
ISSN:	0363-6143 1522-1563