Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension

Genetic and biochemical determinants of abnormal monovalent ion transport in primary hypertension

Data obtained during the last two decades show that spontaneously hypertensive rats, an acceptable experimental model of primary human hypertension, possess increased activity of both ubiquitous and renal cell-specific isoforms of the Na+/H+ exchanger (NHE) and Na+-K+-2Cl- cotransporter.

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1999-03, Vol.45 (3), p.C511
Hauptverfasser: Orlov, Sergei N, Adragna, Norma C, Adarichev, Viacheslav A, Hamet, Pavel
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Cellular biology
Genes
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Zusammenfassung:Data obtained during the last two decades show that spontaneously hypertensive rats, an acceptable experimental model of primary human hypertension, possess increased activity of both ubiquitous and renal cell-specific isoforms of the Na+/H+ exchanger (NHE) and Na+-K+-2Cl- cotransporter.
ISSN:0363-6143
1522-1563