Alteration of Cx43:Cx40 expression ratio in A7r5 cells

Alteration of Cx43:Cx40 expression ratio in A7r5 cells

Connexins (Cx) 40 and 43 are coexpressed by several cell types at ratios that vary as a function of development, aging, and disease. Because these connexins form heteromeric channels, changes in expression ratio might be expected to significantly alter the connexin composition of the gap junction ch...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 2001-03, Vol.49 (3), p.C500-C508
Hauptverfasser: BURT, Janis M, FLETCHER, Anna M, STEELE, Timothy D, YAN WU, COTTRELL, G. Trevor, KURJIAKA, David T
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cell physiology
Cellular biology
Fundamental and applied biological sciences. Psychology
Membrane and intracellular transports
Molecular and cellular biology
Molecules
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Zusammenfassung:Connexins (Cx) 40 and 43 are coexpressed by several cell types at ratios that vary as a function of development, aging, and disease. Because these connexins form heteromeric channels, changes in expression ratio might be expected to significantly alter the connexin composition of the gap junction channel opopulation and, therefore, gap junction function.
ISSN:0363-6143
1522-1563