Glutathione protects chemokine-scavenging and antioxidative defense functions in human RBCs

Oxidant stress, in vivo or in vitro, is known to induce oxidative changes in human red blood cells (RBCs). Our objective was to examine the effect of augmenting RBC glutathione (GSH) synthesis on 1) degenerative proetin loss and 2) RBC chemokin- and free radical-scavenging functions in the oxidative...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-04, Vol.49 (4), p.C867-C873
Hauptverfasser:	DUMASWALA, U. J, ZHUO, L, MAHAJAN, S, NAIR, P. N. M, SHERTZER, H. G, DIBELLO, P, JACOBSEN, D. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood Cell metabolism, cell oxidation Cell physiology Cells Cellular biology Fundamental and applied biological sciences. Psychology Molecular and cellular biology Oxidation
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Oxidant stress, in vivo or in vitro, is known to induce oxidative changes in human red blood cells (RBCs). Our objective was to examine the effect of augmenting RBC glutathione (GSH) synthesis on 1) degenerative proetin loss and 2) RBC chemokin- and free radical-scavenging functions in the oxidatively stressed human RBCs by using banked RBCs as a model.
ISSN:	0363-6143 1522-1563