BK-Ca channel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy

BK-Ca channel activation by membrane-associated cGMP kinase may contribute to uterine quiescence in pregnancy

We investigated the influence of pregnancy on large-conductance calcium-activated potassium channel (BKca) activity (NPo) and on channel expression in membrances of isolated human myometrial smooth muscle cells. NPo in inside-out patches was higher in pregnant myometria (PM) compared with nonpregnan...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American Journal of Physiology: Cell Physiology 2000-12, Vol.48 (6), p.C1751
Hauptverfasser: Xiao-bo, Zhou, Ge-Xin, Wang, Ruth, Peter, Huneke, Bernd, Korth, Michael
Format: Artikel
Sprache:eng
Schlagworte:
Calcium
Cells
Enzymes
Muscular system
Potassium
Pregnancy
Proteins
Reproductive system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We investigated the influence of pregnancy on large-conductance calcium-activated potassium channel (BKca) activity (NPo) and on channel expression in membrances of isolated human myometrial smooth muscle cells. NPo in inside-out patches was higher in pregnant myometria (PM) compared with nonpregnant myometria (NPM), and the half-maximal activation potential was shifted by 39 mV to more negative potentials.
ISSN:0363-6143
1522-1563