Cerebral vascular endothelial heme oxygenase: expression, localization, and activation by glutamate

Endogenous carbon monoxide (CO) contributes to vasodilator responses of cerebral microvessels in newborn pigs. We investigated the expression, intracellular localization, and activity of heme oxygenase (HO), the key enzyme in CO production, in quiescent cerebral microvascular endothelial cells (CMVE...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 2001-12, Vol.50 (6), p.C1954-C1963
Hauptverfasser:	PARFENOVA, Helena, NEFF, Robert A, ALONSO, Julie S, SHLOPOV, Boris V, JAMAL, Chaklader N, SARKISOVA, Svetlana A, LEFFLER, Charles W
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood vessels Brain Carbon monoxide Cells Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Enzymes Fundamental and applied biological sciences. Psychology Hogs Vertebrates: nervous system and sense organs
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Zusammenfassung:	Endogenous carbon monoxide (CO) contributes to vasodilator responses of cerebral microvessels in newborn pigs. We investigated the expression, intracellular localization, and activity of heme oxygenase (HO), the key enzyme in CO production, in quiescent cerebral microvascular endothelial cells (CMVEC) from newborn pigs.
ISSN:	0363-6143 1522-1563