Alterations in AMP deaminase activity and kinetics in skeletal muscle of creatine kinase-deficient mice

Alterations in AMP deaminase activity and kinetics in skeletal muscle of creatine kinase-deficient mice

Alterations in the competency of the creatine kinase system elicit numerous structural and metabolic compensations, including changes in purine nucleotide metabolism. We evaluated molecular and kinetic changes in AMP deaminase from skeletal muscles of mice deficient in either cytosolic creatine kina...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 1998-05, Vol.43 (5), p.C1411-C1416
Hauptverfasser: TULLSON, P. C, RUSH, J. W. E, WIERINGA, B, TERJUNG, R. L
Format: Artikel
Sprache:eng
Schlagworte:
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Enzymes
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Hydrolases
Kinetics
Muscular system
Rodents
Skeletal system
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Zusammenfassung:Alterations in the competency of the creatine kinase system elicit numerous structural and metabolic compensations, including changes in purine nucleotide metabolism. We evaluated molecular and kinetic changes in AMP deaminase from skeletal muscles of mice deficient in either cytosolic creatine kinase alone (M-CK-/-) or also deficient in mitochondrial creatine kinase (CK-/-) compared with wild type.
ISSN:0363-6143
1522-1563