Control of Ca2+ wave propagation in mouse pancreatic acinar cells

We have investigated control mechanisms involved in the propagation of agonist induced Ca2+ waves in isolated mouse pancreatic acinar cells. Using a confocal laser-scanning microscope, we were able to show that maximal stimulation of cells with acetylcholine (ACh, 500 nM) or bombesin (1 nM) caused a...

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Veröffentlicht in:	American Journal of Physiology: Cell Physiology 1998-03, Vol.43 (3), p.C663-C672
Hauptverfasser:	PFEIFFER, F, STERNFELD, L, SCHMID, A, SCHULZ, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Biological and medical sciences Cell physiology Cellular biology Enzymes Fundamental and applied biological sciences. Psychology Membrane and intracellular transports Molecular and cellular biology Pancreas Proteins Rodents
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Zusammenfassung:	We have investigated control mechanisms involved in the propagation of agonist induced Ca2+ waves in isolated mouse pancreatic acinar cells. Using a confocal laser-scanning microscope, we were able to show that maximal stimulation of cells with acetylcholine (ACh, 500 nM) or bombesin (1 nM) caused an initial Ca2+ release of comparable amounts with both agonists at the luminal cell pole.
ISSN:	0363-6143 1522-1563