Peroxynitrite causes endothelial cell monolayer barrier dysfunction

Peroxynitrite causes endothelial cell monolayer barrier dysfunction

Nitrix oxide (NO) attenuates hydrogen peroxide (H2O2)-mediated barrier dysfunction in cultured porcine pulmonary artery endothelial cells (PAEC) (Gupta MP, Ober MD, Patterson C, Al-Hassani M, Natarajan V, and Hart, CM. Am J Physiol Lung Cell Mol Physiol 280: L116-L126, 2001). However, NO rapidly com...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American Journal of Physiology: Cell Physiology 2001-09, Vol.50 (3), p.C1064-C1075
Hauptverfasser: KNEPLER, James L, TAHER, Loui N, GUPTA, Mahesh P, PATTERSON, Carolyn, PAVALKO, Fred, OBER, Michael D, HART, C. Michael
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Blood vessels
Blood vessels and receptors
Cellular biology
Fundamental and applied biological sciences. Psychology
Hogs
Lymphatic system
Vertebrates: cardiovascular system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Nitrix oxide (NO) attenuates hydrogen peroxide (H2O2)-mediated barrier dysfunction in cultured porcine pulmonary artery endothelial cells (PAEC) (Gupta MP, Ober MD, Patterson C, Al-Hassani M, Natarajan V, and Hart, CM. Am J Physiol Lung Cell Mol Physiol 280: L116-L126, 2001). However, NO rapidly combines with superoxide (O-/2) to form thed powerful oxidant peroxynitrite (ONOO-), which we hypothesized would cause PAEC monolayer barrier dysfunction.
ISSN:0363-6143
1522-1563